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Glossary

Migraine-Related Terms

Agonist

A chemical that mimics or copies the actions of another chemical.

Aura

A warning signal of migraine experienced by approximately 20% of sufferers. Aura may be a visual (eg, seeing flashing lights or zig-zag lines), auditory, or other sensory or physical disturbance. Aura occurs before the actual headache.

Dilation

A condition in which a body cavity, tube, artery, pupil of the eye, or opening is enlarged or stretched as a result of a normal physiological process or because of disease or a medical procedure.

Onset

The first noticeable symptoms. For most, head pain is the first sign of a migraine attack.

Prodromes

Warning signals that can occur well in advance (hours or days) of the onset of symptoms.

Serotonin

A substance that occurs naturally in the body. It has been found that the serotonin level in a migraine sufferer's brain first rises, then falls dramatically at the onset of an attack, provoking a theory that serotonin plays an important role in migraine.

Trigger

A specific event or substance that directly leads to an event in some patients. Common triggers include, but are not limited to, food, activity, light, sounds, smells, caffeine, nicotine, certain medications, and changes in diet.

Important Safety Information about TREXIMET
TREXIMET may increase the risk of heart attack, stroke, serious stomach and intestinal problems such as bleeding and ulcers, and serious rash that may be fatal and occur without warning. Risk of stomach and intestinal problems increases in the elderly.

Do not take TREXIMET if you have a history of heart or liver disease, stroke, TIAs, problems with blood circulation, uncontrolled blood pressure, or allergic reaction to aspirin, NSAIDs, or sumatriptan (Imitrex^®); or right before or after heart surgery called coronary artery bypass graft (CABG).

Talk to your doctor before taking TREXIMET if you have risk factors for heart disease like high blood pressure, high cholesterol, smoking, obesity, diabetes, family history of heart disease, are a post-menopausal female, or male over age 40.

Talk to your doctor before taking TREXIMET if you have stomach ulcers or bleeding; chest pain, shortness of breath, irregular heartbeats; kidney problems; are pregnant, nursing, or thinking about becoming pregnant; or taking medications, especially pain relievers or antidepressants. Serotonin syndrome, a life-threatening problem, may occur with TREXIMET, especially if used with antidepressants called SSRIs or SNRIs. Do not take TREXIMET if you have taken an MAOI antidepressant within the last 2 weeks. TREXIMET should only be used exactly as prescribed, at the lowest dose and for the shortest time possible.