Important Safety Information
Prescribing Information (see boxed WARNINGS) and Medication Guide
TREXIMET may increase the risk of heart attack, stroke, serious stomach and intestinal problems such as bleeding and ulcers, and serious rash that may be fatal and occur without warning. Risk of stomach and intestinal problems increases in the elderly (see boxed WARNINGS). Continued Below
Taking TREXIMET
At the office, in your car, on vacation – you never know when or where a migraine attack will happen. Headache experts agree that it’s best to treat migraines at the first sign of pain, so you should try to keep your medication on hand at all times. Always take TREXIMET as instructed by your doctor. Each prescription for TREXIMET comes with 9 tablets in a convenient, flip-top container, making it easy to carry with you when you're on the go.
| Each prescription for TREXIMET comes with 9 tablets in a convenient, flip-top container. |  |
How to use TREXIMET:
- Take 1 TREXIMET tablet to treat your migraine headache
- Do not take more than 2 TREXIMET tablets in 24 hours; the efficacy of taking a second dose has not been established
- Doses should be separated by at least 2 hours
- Do not split, crush, or chew TREXIMET tablets
- TREXIMET can be taken with or without food
- For the medication to work properly, it must be taken as prescribed
- The safety of treating more than 5 migraines in a 30-day period has not been established
Establishing open communication with your doctor is a key step in becoming more aware of your condition and finding treatment that meets your specific needs. For advice to help you start that conversation see our doctor discussion guide.
It's important to remember that each migraine patient is different and you're the only one who knows what migraine pain is like for you. Always be honest with your doctor about your condition. He or she can help find a treatment that’s right for you. Ask if TREXIMET can help.
Prescription TREXIMET is for the acute treatment of migraine attacks in adults.
Important Safety Information About TREXIMET
TREXIMET may increase the risk of heart attack, stroke, serious stomach and intestinal problems such as bleeding and ulcers, and serious rash that may be fatal and occur without warning. Risk of stomach and intestinal problems increases in the elderly.
Do not take TREXIMET if you have a history of heart or liver disease, stroke, TIAs, problems with blood circulation, uncontrolled blood pressure, or allergic reaction to aspirin, NSAIDs, or sumatriptan (Imitrex®); or right before or after heart surgery called coronary artery bypass graft (CABG).
Talk to your doctor before taking TREXIMET if you have risk factors for heart disease like high blood pressure, high cholesterol, smoking, obesity, diabetes, family history of heart disease, are a post-menopausal female, or male over age 40.
Talk to your doctor before taking TREXIMET if you have stomach ulcers or bleeding; chest pain, shortness of breath, irregular heartbeats; kidney problems; asthma; Crohn's disease or ulcerative colitis; are pregnant, nursing, or thinking about becoming pregnant; or taking medications, especially pain relievers or antidepressants. TREXIMET should not be used in late pregnancy (third trimester) because TREXIMET can harm your unborn baby. TREXIMET should not be used if you are breastfeeding or plan to breastfeed because TREXIMET passes into your breast milk and may harm your baby. Serotonin syndrome, a life-threatening problem, may occur with TREXIMET, especially if used with antidepressants called SSRIs or SNRIs. Do not take TREXIMET if you have taken an MAOI antidepressant within the last 2 weeks. Do not take TREXIMET if you have taken ergotamine-containing medicines or other triptans within the last 24 hours. TREXIMET should only be used exactly as prescribed, at the lowest dose and for the shortest time possible.
Some people who take TREXIMET too often may have worse headaches. If your headaches get worse, your doctor may stop treatment with TREXIMET. Your doctor may encourage you to track your headache frequency and medication use.